FOLH1 monoclonal antibody, clone GCP-04
产品名称： FOLH1 monoclonal antibody, clone GCP-04
英文名称： FOLH1 monoclonal antibody, clone GCP-04
产品编号： MAB3610
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against partial recombinant FOLH1.
- Immunogen:
- Recombinant protein corresponding to amino acids 44-750 of human FOLH1.
- Host:
- Mouse
- Theoretical MW (kDa):
- 95-110
- Reactivity:
- Human, Pig, Rat
- Specificity:
- This antibody recognizes amino acids 100-104 of extracellular domain of denaturated glutamate carboxypeptidase II (PSMA, NAALADase, FOLH1), an approximately 95-110 KDa transmembrane glycoprotein.
- Form:
- Liquid
- Concentration:
- 1 mg/mL
- Isotype:
- IgG1
- Storage Buffer:
- In PBS, pH 7.4 (15 mM sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- GSK-3beta-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle.
Mukherji A, Janbandhu VC, Kumar V.FEBS Lett. 2008 Apr 2;582(7):1111-6. Epub 2008 Mar 6.
- 2.
- Myostatin induces cyclin D1 degradation to cause cell cycle arrest through a phosphatidylinositol 3-kinase/AKT/GSK-3 beta pathway and is antagonized by insulin-like growth factor 1.
Yang W, Zhang Y, Li Y, Wu Z, Zhu D.J Biol Chem. 2007 Feb 9;282(6):3799-808. Epub 2006 Nov 27.
- 3.
- Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization.
Diehl JA, Cheng M, Roussel MF, Sherr CJ.Genes Dev. 1998 Nov 15;12(22):3499-511.
- Applications
- Western Blot (Recombinant protein)
- Immunostaining of a fragment of human FOLH1 (amino acids 44-750) produced in S2 cells on Western blot by FOLH1 monoclonal antibody, clone GCP-04 (Cat # MAB3610).
Lanes 1, 2, 3 represent 800, 400 and 200 pg of the protein.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry of FOLH1 in human medulla oblongata by FOLH1 monoclonal antibody, clone GCP-04 (Cat # MAB3610). Mag. 40x ; positive astrocytes in white matter.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Immunohistochemistry of FOLH1 in porcine kidney by FOLH1 monoclonal antibody, clone GCP-04 (Cat # MAB3610). Highly positive proximal glomeruli.
- Application Image
- Western Blot (Recombinant protein)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Immunocytochemistry
- Entrez GeneID:
- 2346
- Gene Name:
- FOLH1
- Gene Alias:
- FGCP,FOLH,GCP2,GCPII,NAALAD1,NAALAdase,PSM,PSMA,mGCP
- Gene Description:
- folate hydrolase (prostate-specific membrane antigen) 1
- Omim ID:
- 600934
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
- Other Designations:
- N-acetylated alpha-linked acidic dipeptidase 1,cell growth-inhibiting protein 27,folate hydrolase 1,folylpoly-gamma-glutamate carboxypeptidase,glutamate carboxylase II,glutamate carboxypeptidase II,membrane glutamate carboxypeptidase,prostate specific mem
- Related Disease
- Aortic Aneurysm, Abdominal
- Atherosclerosis
- Brain Ischemia
- Cardiovascular Diseases
- Chromosome Aberrations
- Cleft Lip
- Cleft Palate
- Cognition
- Colorectal Neoplasms
- Coronary Disease
- Diabetes Mellitus, Type 2
- DNA Damage
- Edema
- Genetic Predisposition to Disease
- Hyperhomocysteinemia
- Hypertension
- Kidney Failure, Chronic
- Micronuclei, Chromosome-Defective
- Neural Tube Defects