CD63 monoclonal antibody, clone MEM-259 (PerCP)
产品名称： CD63 monoclonal antibody, clone MEM-259 (PerCP)
英文名称： CD63 monoclonal antibody, clone MEM-259 (PerCP)
产品编号： MAB6493
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against native CD63.
- Immunogen:
- Native purified CD63 from HPB-ALL T cell line.
- Host:
- Mouse
- Theoretical MW (kDa):
- 40-60
- Reactivity:
- Human
- Specificity:
- This antibody reacts with CD63 (LAMP-3), a 40-60 KDa tetraspan glycoproteinexpressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelialcells. Cell surface exposition of CD63 is usually activation-dependent.
- Form:
- Liquid
- Conjugation:
- PerCP
- Isotype:
- IgG1
- Storage Buffer:
- In PBS (0.2% BSA, 15 mM sodium azide)
- Storage Instruction:
- Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH.J Biol Chem. 2008 Mar 21;283(12):7674-81. Epub 2008 Jan 22.
- 2.
- CD63 as a biomarker for predicting the clinical outcomes in adenocarcinoma of lung.
Kwon MS, Shin SH, Yim SH, Lee KY, Kang HM, Kim TM, Chung YJ.Lung Cancer. 2007 Jul;57(1):46-53. Epub 2007 Mar 12.
- 3.
- The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing.
Cerny J, Feng Y, Yu A, Miyake K, Borgonovo B, Klumperman J, Meldolesi J, McNeil PL, Kirchhausen T.EMBO Rep. 2004 Sep;5(9):883-8.
- Applications
- Immunofluorescence
- Immunofluorescence staining of CD63 in human HeLa cell line using CD63 monoclonal antibody, clone MEM-259 (Cat # MAB0931, green). Actin cytoskeleton was decorated by phalloidin (red) and cell nuclei stained with DAPI (blue) .
- Entrez GeneID:
- 967
- Gene Name:
- CD63
- Gene Alias:
- LAMP-3,ME491,MLA1,OMA81H,TSPAN30
- Gene Description:
- CD63 molecule
- Omim ID:
- 155740
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. The use of alternate polyadenylation sites has been found for this gene. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq
- Other Designations:
- CD63 antigen,CD63 antigen (melanoma 1 antigen),granulophysin,lysosome-associated membrane glycoprotein 3,melanoma 1 antigen,melanoma-associated antigen ME491,melanoma-associated antigen MLA1,ocular melanoma-associated antigen,tetraspanin-30
- Gene Pathway